Identified Mutations Sequencing of the entire coding region of KCNJ10 revealed a homozygous missense mutation, c.R65P), in the four affected individuals in Family members 1 and another homozygous missense mutation, c.G77R), in Patient 2-1 . Parents had been heterozygous for the particular mutations . Sequencing of 192 matched control alleles did not reveal the sequence variation p ethnically.R65P, identified in Family 1.The findings were published online ahead of the printing edition of the American Thoracic Society’s American Journal of Respiratory and Essential Care Medicine. The etiology of severe exacerbation of IPF remains unidentified, and occult viral illness provides been proposed as you possible cause, stated Harold Collard, MD, director of the Interstitial Lung Disease Plan at the University of California, San Francisco. The results of the study suggest that the majority of cases of acute exacerbation of IPF are not due to viral contamination.