Kristian Reich.

Kristian Reich, M.D., Richard G http://silagracipla.net/reviews . Langley, M.D., Kim A. Papp, M.D., Jean-Paul Ortonne, M.D., Kristina Unnebrink, Ph.D., Martin Kaul, M.D., and Joaquin M. Valdes, M.D.3,4 Interleukin-12 and interleukin-23 play important functions in the pathogenesis of psoriasis. The shared p40 subunit of interleukin-12 and interleukin-23 is usually overexpressed in psoriatic epidermis lesions5-7 and is associated with psoriasis in genetic research. Although now there is strong evidence supporting the efficacy of biologic therapy for the treatment of psoriasis,15 there is a need to compare the efficacy and basic safety of biologic agents with those of traditional systemic therapies such as methotrexate, which may be the most commonly prescribed systemic therapy for psoriasis worldwide.16 We evaluated the efficacy and safety of just one 1 year of treatment with briakinumab as compared with methotrexate in individuals with moderate-to-severe plaque psoriasis.

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