Robert Provenzano.

Iain C . Macdougall, M.D., Robert Provenzano, M.D., Amit Sharma, M.D., Bruce S. Spinowitz, M.D., Rebecca J. Schmidt, D.O., Pablo E. Pergola, M.D., Ph.D., Raja I. Zabaneh, M.D., Sandra Tong-Starksen, M.D., Martha R. Mayo, Pharm.D., Hong Tang, M.S., Krishna R. Polu, M.D., Anne-Marie Duliege, M.D., and Steven Fishbane, M.D. For the PEARL Study Groups: Peginesatide for Anemia in Individuals with Chronic Kidney Disease Not really Receiving Dialysis The 1989 approval of recombinant individual erythropoietin facilitated sustained correction of anemia in chronic kidney disease and freed many individuals undergoing dialysis from reliance on transfusions.1,2 Increases in hemoglobin levels from approximately 6 to 7 g per deciliter to approximately 11 to 12 g per deciliter improved symptoms, quality of life, and physical capacity.3,4 Subsequent molecular modifications generated two erythropoiesis-stimulating agents with longer in vivo half-lives , offering the potential of less frequent administration.5-7 Both derive from the endogenous erythropoietin molecule.8 Peginesatide , a peptide-based ESA,9,10 was approved in the usa in March 2012 for the treating anemia due to chronic kidney disease in adults who also are undergoing dialysis.

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